Placebo Effect—Not Antidepressants—Responsible for Depression Improvement
Mad in America
DECEMBER 25, 2023
In a study of fluoxetine (Prozac) for adolescents, researchers found that the placebo effect predicted good outcomes, but the actual drug treatment did not. After accounting for “treatment guess” (those who figured out that they were receiving an intervention rather than placebo), the drug was not effective in depression treatment. In fact, those who received a placebo but thought they received Prozac improved more than those who received the drug and knew it.
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